What are the possible side effects of M-Enalapril?
Get emergency medical help if you have any signs of an allergic reaction to M-Enalapril: hives; severe stomach pain; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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a light-headed feeling, like you might pass out;
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pounding heartbeats or fluttering in your chest;
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high potassium - slow heart rate, weak pulse, muscle weakness, tingly feeling;
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low white blood cell counts - sudden weakness or ill feeling, fever, chills, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or
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signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath.
Common M-Enalapril side effects may include:
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dizziness, tired feeling;
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cough; or
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feeling light-headed.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Side effects of M-Enalapril in details
M-Enalapril MALEATE (M-Enalapril) has been demonstrated to be generally well tolerated. In clinical studies, the overall incidence of side effects was no greater with M-Enalapril MALEATE (M-Enalapril) than with placebo. For the most part, side effects have been mild and transient in nature, and have not required discontinuation of therapy.
The following side effects have been associated with the use of Tablets M-Enalapril MALEATE (M-Enalapril): Dizziness and headache were the more commonly reported side effects. Fatigue and asthenia were reported in 2-3% of patients. Other side effects occurred in less than 2% of patients, and included hypotension, orthostatic hypotension, syncope, nausea, diarrhea, muscle cramps, rash, and cough. Less frequently renal dysfunction, renal failure, and oliguria have been reported.
Hypersensitivity/Angioneurotic Edema: Angioneurotic edema of the face, extremities, lips, tongue, glottis and/or larynx has been reported rarely. In very rare cases, intestinal angioedema has been reported with angiotensin converting enzyme inhibitors including M-Enalapril.
Side effects which occurred very rarely, either during controlled clinical trials or after the drug was marketed, include: Cardiovascular: Myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients, chest pain, palpitations, rhythm disturbances, angina pectoris, Raynaud's phenomenon.
Endocrine: Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Gastrointestinal: Ileus, pancreatitis, hepatic failure, hepatitis - either hepatocellular or cholestatic, jaundice, abdominal pain, vomiting, dyspepsia, constipation, anorexia, stomatitis.
Metabolic: Cases of hypoglycemia in diabetic patients on oral antidiabetic agents or insulin have been reported.
Nervous System/Psychiatric: Depression, confusion, somnolence, insomnia, nervousness, paresthesia, vertigo, dream abnormality.
Respiratory: Pulmonary infiltrates, bronchospasm/asthma, dyspnea, rhinorrhea, sore throat and hoarseness.
Skin: Diaphoresis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, pemphigus, pruritus, urticaria, alopecia.
Other: Impotence, flushing, taste alteration, tinnitus, glossitis, blurred vision.
A symptom complex has been reported which may include some or all of the following: Fever, serositis, vasculitis, myalgia/myositis, arthralgia/arthritis, a positive ANA, elevated ESR, eosinophilia, and leukocytosis. Rash, photosensitivity or other dermatologic manifestations may occur.
Laboratory Test Findings: Clinically important changes in standard laboratory parameters were rarely associated with administration of M-Enalapril MALEATE (M-Enalapril). Increases in blood urea and serum creatinine, and elevations of liver enzymes and/or serum bilirubin have been seen. These are usually reversible upon discontinuation of M-Enalapril MALEATE (M-Enalapril). Hyperkalemia and hyponatremia have occurred.
Decreases in hemoglobin and hematocrit have been reported.
Since the drug was marketed a small number of cases of neutropenia, thrombocytopenia, bone marrow depression, and agranulocytosis have been reported in which a causal relationship to therapy with M-Enalapril MALEATE (M-Enalapril) could not be excluded.
What is the most important information I should know about M-Enalapril?
- M-Enalapril solution may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use M-Enalapril solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- M-Enalapril solution may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. If light-headedness occurs, especially during the first few days of treatment, contact your doctor.
- Do NOT take more than the recommended dose without checking with your doctor.
- Check with your doctor before you use a salt substitute or a product that has potassium in it.
- Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.
- M-Enalapril solution may cause a dry, unproductive cough. If caused by M-Enalapril solution, this symptom usually stops after treatment with M-Enalapril solution is stopped.
- M-Enalapril solution may cause a serious side effect called angioedema. The risk may be higher in black patients. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
- Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
- If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
- M-Enalapril solution may not work as well in black patients. Contact your doctor if your symptoms do not improve or if they become worse.
- M-Enalapril solution may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to M-Enalapril solution. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Rarely, M-Enalapril solution may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Tell your doctor or dentist that you take M-Enalapril solution before you receive any medical or dental care, emergency care, or surgery.
- Lab tests, including blood pressure monitoring, blood electrolyte levels, and kidney function, may be performed while you take M-Enalapril solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- M-Enalapril solution should not be used in NEWBORNS; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: M-Enalapril solution may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. M-Enalapril solution is found in breast milk. Do not breast-feed while taking M-Enalapril solution.
M-Enalapril contraindications
Do not use this medication if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant.
You should not use this medication if you are allergic to M-Enalapril, or similar medicines such as such as benazepril (Lotensin), captopril (Capoten Capozide), fosinopril (Monopril), lisinopril (Prinivil, Prinzide, Zestoretic, Zestril), moexipril (Univasc, Uniretic), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), trandolapril (Mavik, Tarka), and others.
Before you take M-Enalapril, tell your doctor if you have kidney or liver disease, heart disease, diabetes, or a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis.
Tell your doctor about all other medicines you use.
Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking M-Enalapril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
If you need surgery, tell the surgeon ahead of time that you are using M-Enalapril. You may need to stop using the medicine for a short time. Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested. Visit your doctor regularly.
References
- DailyMed. "ENALAPRIL MALEATE; HYDROCHLOROTHIAZIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
- HSDB. "ENALAPRIL MALEATE". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for M-Enalapril are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking M-Enalapril. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
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Information checked by Dr. Sachin Kumar, MD Pharmacology
